Indications Of Fresh Frozen Plasma (FFP)

  • Single-factor deficiencies.

  • Multiple-factor deficiencies, hypo/dysfibrinogenemia, and/or disseminated intravascular coagulopathy

  • Thrombotic thrombocytopenic purpura.

  • Need for urgent reversal of warfarin effect

  • Vitamin K deficiency

  • Liver disease, especially in the setting of liver biopsy

  • Preparation for invasive bedside procedures

  • During intraoperative cardiopulmonary bypass

  • For massive transfusion

  • Hemorrhagic disease of the newborn

  • Inherited deficiencies of clotting factors.

  • Coagulopathy and bleeding, or coagulopathy with planned procedure.

  • Prevention of red blood cell hemolysis related to red cell T antigen activation

  • Hypovolemia

  • Plasma exchange.

  • Reversal of prolonged INR in the absence of bleeding

  • Prevention of intraventricular hemorrhage in preterm infants

  • Treatment of neonates with polycythemia

  • Wound healing.

  • Other inappropriate uses.

    In addition, frozen plasma should not be used for

  nutritional support, protein-losing states, Guillain-Barré syndrome,  acute pancreatitis or burns